Synthesis, Characterization and Evaluation of Anti-microbial Activity of Some Novel 1,2,4-triazoles

Some novel 4-(aryliidineamino)-5-(1-(4-isobutylphenyl) ethyl)-4-yl-4H-1,2,4-triazole-3-thiols were prepared from the reaction of carbon-di-sulphide and hydrazine hydrate in water to produce thiocarbohydrazides. The thiocarbohydrazides is then refluxed with ibuprofen for 2 hour, followed by cooling to room temperature and washing with sodium bicarbonate solution to produce 5-(1-(4isobutylphenyl) ethyl)-4H-1,2,4triazole-3-thiole. It is then refluxed with different aldehydes in the presence of ethanol and HCl to produce the title compounds. The synthesized compounds are recrystallized from ethanol and are analyzed for their physical and spectral data. The test compound T6 shows significant activity compared to Aspirin which was also employed both of which were employed at a dose of 200mg/kg. The fact that the test compound acted orally shows that there is better absorption and it is not degradable in GIT.